21世纪末，人类的科技水平已高度发达，克隆人技术和宇宙航行早已实现，不再是梦想
与此同时，许多科学家仍孜孜不倦追索着人类起源的秘密与真相 通过对许多古老文明的考察与对比，科学家伊丽莎白·肖（Noomi Rapace 饰）和查理·赫洛维（Logan Marshall-Green 饰）发现，人类可能是来自一个遥远星系的外星人创造的 在Weyland公司资助下，他们乘坐维克丝（查理兹·塞隆 Charlize Theron 饰）所掌管的宇宙飞船普罗米修斯号前往那颗未知的星球
经过对当地的考察，地球人的设想成功得到印证 可是他们贸然探查“神的秘密”的行为，也将自己引入万劫不复的深渊
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